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How Is Akt Inactivated? [Solved]
PTEN remains active due to inactivation of its negative regulator Src-p60. The low levels of Src-p60 may also contribute to direct attenuation of PDK-1 activity. These effects will result in inactivation of Akt by loss of phosphorylation at Thr-308 and Ser-473.
AKT inactivation mediated by a PP2A switch after GqPCR activation
Nadel, et al. “GqPCR-stimulated dephosphorylation of
AKT Signaling Pathway | Regulation and Downstream Effects
Biomedical lesson on
The Study of Akt
This video provides in-depth information on upstream and downstream signaling mechanisms stemming from
